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ID 30399
本文ファイル
著者
Makihira, Seicho
Shuto, Takahiro
Okamoto, Keishi
Mine, Yuichi
Takamoto, Yuko
Tsuji, Koichiro
キーワード
antimicrobial peptide
titanium surface
MC3T3-E1 cells
NDC
医学
抄録(英)
The objective of this study was to evaluate the effect of titanium immobilized with a cationic antimicrobial peptide (JH8194) derived from histatin on the biofilm formation of Porphyromonas gingivalis and differentiation of osteoblastic cells (MC3T3-E1). The titanium specimens (Ti) were immobilized with JH8194, according to the method previously described. The colonization of P. gingivalis on JH8194-Ti was significantly lower than that on control- and blocking-Ti. JH8194-Ti enhanced the mRNA expressions of Runx2 and OPN, and ALPase activity in the MC3T3-E1, as compared with those of control- and blocking-Ti. These results, taken together, suggested the possibility that JH8194-Ti may be a potential aid to shorten the period of acquiring osseointegration.
掲載誌名
International Journal of Molecular Sciences
11巻
4号
開始ページ
1458
終了ページ
1470
出版年月日
2010-04-02
出版者
Molecular Diversity Preservation International-MDPI
ISSN
1422-0067
NCID
出版者DOI
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
権利情報
Copyright (c) 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.
関連情報URL
部局名
医歯薬学総合研究科