このエントリーをはてなブックマークに追加
ID 50461
著者
Ando, Yuwa
Suehiro, Yosuke
Yamaoka, Kenji
Kosaka, Yumi
Fuji, Yasutomo
Uchikawa, Shinsuke
Kodama, Kenichiro
Morio, Kei 大学院医系科学研究科(医) 広大研究者総覧
Nakahara, Takashi
Ono, Atsushi
Takahashi, Shoichi
Tsuge, Masataka 自然科学研究支援開発センター 広大研究者総覧
Chayama, Kazuaki 大学院医系科学研究科(医) 広大研究者総覧
Aikata, Hiroshi 大学院医系科学研究科(医) 広大研究者総覧
キーワード
Hepatocellular carcinoma
Mismatch repair deficiency
MSI-high
Immune checkpoint blockade
PD-L1
抄録(英)
Hepatocellular carcinoma (HCC) has limited systemic treatment options and a poor prognosis. The immune checkpoint inhibitor pembrolizumab was recently approved for the treatment of solid tumors with microsatellite instability (MSI). However, its clinical utility for the management of HCC remains to be clarified. Here, we present a case of unresectable HCC with MSI that showed an impressive response to pembrolizumab treatment. A 64-year-old man with chronic HCV infection was diagnosed with a large HCC. His severe liver dysfunction and poor performance status prevented any treatment option other than sorafenib. However, sorafenib failed after a few days due to the rapid progression of the tumor. Based on the finding of MSI in a biopsy specimen, immunotherapy using pembrolizumab was initiated. A dramatic improvement in his general condition and a reduction in tumor size were observed after the initiation of pembrolizumab treatment. Among a cohort of 50 consecutive patients with advanced HCC who were refractory to standard systemic therapy, MSI was found only in the present case. Immune checkpoint blockade therapy induced prominent anti-tumor effects in HCC with MSI. Screening for defects in DNA mismatch repair function may be warranted in HCC patients despite the low frequency of MSI.
掲載誌名
Clinical Journal of Gastroenterology
13巻
5号
開始ページ
867
終了ページ
872
出版年月日
2020-10
出版者
Springer
ISSN
1865-7257
1865-7265
出版者DOI
PubMedID
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
author
権利情報
This is a post-peer-review, pre-copyedit version of an article published in Clinical Journal of Gastroenterology. The final authenticated version is available online at: https://doi.org/10.1007/s12328-020-01099-3
This is not the published version. Please cite only the published version. この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。
関連情報URL
部局名
医系科学研究科
病院
自然科学研究支援開発センター
備考
Post-print version/PDF may be used in an institutional repository after an embargo period of 12 months.