このエントリーをはてなブックマークに追加
ID 38132
本文ファイル
著者
Hiraoka, Yukio
Imada, Atsushi
Okuda, Hisanori
キーワード
Degraded and undegrnded fenitrothion emulsion
Mouse
Embryo
Toxicity
NDC
医学
抄録(英)
Experiments were carried out to examine the effects of degradation products on mice. Fenitrothion (MEP) emulsion, a kind of an organic phosphorous insecticide, adjusted to pH 8, pH 10, and pH 14 were degraded by exposure to natural sunlight. Physiological saline, an untreated MEP emulsion, and the three degraded solutions were prepared as experimental chemicals and were administered subcutaneously at a dosage of 0.1 ml/10 g body weight (BW) into the backs of pregnant mice once a day, from the 3rd to the 15th fetal day. Each dose included 20, 40, or 90 mg/kgBW of MEP and several degradation products of MEP. LD50 was determined according to Behrens' method.

The mean fetal body weights of 18th day of pregnancy in 40 and 90 mg/kgBW of MEP of the pH 8 degraded solution were 1.09 and 1.16 g, respectively, significantly lower than that of untreated MEP emulsion (1.27 g). Further, LD50 values of the three kinds of degraded solutions were 60-120 mg/kgBW, much lower than that of the untreated MEP emulsion (410 mg/kgBW).

These results indicate that the degradation products of MEP emulsion degraded by the exposure of sunlight have an influence on both adult and fetal mice.
内容記述
This study was supported by a Grant-in-Aid for General Scientific Research from the Ministry of Education, Science, and Culture.
掲載誌名
Hiroshima Journal of Medical Sciences
38巻
4号
開始ページ
209
終了ページ
212
出版年月日
1989-12
出版者
Hiroshima University Medical Press
ISSN
0018-2052
NCID
PubMedID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
部局名
医歯薬学総合研究科
他の一覧