Different stabilities of liposomes containing saturated and unsaturated lipids toward the addition of cyclodextrins
この文献の参照には次のURLをご利用ください : https://ir.lib.hiroshima-u.ac.jp/00046202
ID | 46202 |
本文ファイル | |
著者 |
Funada, Rikushi
Sugikawa, Kouta
大学院工学研究科
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NDC |
化学
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抄録(英) | Liposomes composed of unsaturated lipids were more stable than those containing saturated lipids toward DMe‐β‐CDx, DMe‐α‐CDx and DMe‐β‐CDx. The Hill coefficient values (n) indicated that the saturated lipid•DMe‐CDx complexes had stoichiometric ratios in the range of 1:3‒1:4, while the unsaturated lipid•DMe‐CDx complexes had ratios in the range of 1:1.5‒1:3. That is, a cis alkene group in the unsaturated lipids prevented complexation with a second DMe‐CDx in the direction toward each acyl chain. Furthermore, the liposomes composed of the unsaturated lipids were much slower to form precipitates upon the addition of α‐CDx than those of the saturated lipids. To the best of our knowledge, this is the first example showing that CDxs interact with unsaturated lipids.
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内容記述 | This work was supported by the Japanese Society for the Promotion of Science (JSPS) KAKENHI a Grant‐in‐Aid for Scientific Research (B) (Grant No. 25288037 and No. 16H04133) and a Grant‐in‐Aid for Challenging Exploratory Research (Grant No. 16K13982).
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掲載誌名 |
Organic and Biomolecular Chemistry
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巻 | 14巻
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号 | 22号
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開始ページ | 5065
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終了ページ | 5072
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出版年月日 | 2016-06-04
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出版者 | Royal Society of Chemistry
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ISSN | 1477-0520
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出版者DOI | |
PubMedID | |
言語 |
英語
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NII資源タイプ |
学術雑誌論文
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広大資料タイプ |
学術雑誌論文
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DCMIタイプ | text
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フォーマット | application/pdf
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著者版フラグ | author
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権利情報 | Copyright (c) 2016 The Royal Society of Chemistry
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
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部局名 |
工学研究科
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