Glioblastoma treated with postoperative radio-chemotherapy : Prognostic value of apparent diffusion coefficient at MR imaging
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ID | 30408 |
本文ファイル | |
著者 |
Abe, Nobukazu
Akiyama, Yuuji
Takaba, Junko
Vishwa, Jeet Amatya
Kajiwara, Yoshinori
Hanaya, Ryosuke
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キーワード | Apparent diffusion coefficient
Echo planar imaging
Glioblastoma
Magnetic resonance imaging
Overall survival
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NDC |
医学
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抄録(英) | Purpose: To retrospectively evaluate whether the mean, minimum, and maximum apparent diffusion coefficient (ADC) of glioblastomas obtained from pretreatment MR images is of prognostic value in patients with glioblastoma.
Materials and methods: The institutional review board approved our study and waived the requirement for informed patient consent. Between February 1998 and January 2006, 33 patients (24 males, 9 females; age range 10–76 years) with supratentorial glioblastoma underwent pretreatment magnetic resonance (MR) imaging. The values of the mean, minimum, and maximum ADC (ADCmean, ADCMIN, and ADCMAX, respectively) of each tumor were preoperatively determined from several regions of interest defined in the tumors. After surgical intervention, all patients underwent irradiation and chemotherapy performed according to our hospital protocol. The patient age, symptom duration, Karnofsky performance scale score, extent of surgery, and ADC were assessed using factor analysis of overall survival. Prognostic factors were evaluated using Kaplan–Meier survival curves, the log-rank test, and multiple regression analysis with the Cox proportional hazards model. Results: Likelihood ratio tests confirmed that ADCMIN was the strongest among the three prognostic factors. Total surgical removal was the most important predictive factor for overall survival (P < 0.01). ADCMIN was also statistically correlated with overall survival (P < 0.05) and could be used to classify patients into different prognostic groups. Interestingly, ADCMIN was also the strongest prognostic factor (P < 0.01) in the group of patients in whom total tumor removal was not possible. Conclusion: The ADCMIN value obtained from pretreatment MR images is a useful clinical prognostic biomarker in patients with glioblastoma. |
掲載誌名 |
European Journal of Radiology
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巻 | 73巻
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号 | 3号
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開始ページ | 532
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終了ページ | 537
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出版年月日 | 2010-03
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出版者 | Elsevier Ireland LTD
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ISSN | 0720-048X
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NCID | |
出版者DOI | |
言語 |
英語
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NII資源タイプ |
学術雑誌論文
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広大資料タイプ |
学術雑誌論文
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DCMIタイプ | text
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フォーマット | application/pdf
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著者版フラグ | author
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権利情報 | Copyright (c) 2009 Elsevier Ireland Ltd
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関連情報URL | |
部局名 |
医歯薬学総合研究科
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