このエントリーをはてなブックマークに追加
ID 48660
本文ファイル
著者
Matsueda, Satoko
Takamori, Shinzo
Toh, Uhi
Noguchi, Masanori
Yutani, Shigeru
Yamada, Akira
Shichijo, Shigeki
Yamada, Teppei
Suekane, Shigetaka
Kawano, Kouichiro
Sasada, Tetsuro
Hattori, Noboru 大学院医歯薬保健学研究院(医) 広大研究者総覧
Kohno, Nobuoki 大学院医歯薬保健学研究院(医)
Itoh, Kyogo
キーワード
Cancer vaccines
cytotoxic T-Lymphocytes
HLA-A26
IgG
peptide vaccines
抄録(英)
To develop a peptide vaccine for cancer patients with the HLA-A26 allele, which is a minor population worldwide, we investigated the immunological responses of HLA-A26+ ⁄ A26+ cancer patients to four different CTL epitope peptides under personalized peptide vaccine regimens. In personalized peptide vaccine regimens, two to four peptides showing positive peptide-specific IgG responses in pre-vaccination plasma were selected from the four peptide candidates applicable for HLA-A26+ ⁄ A26+ cancer patients and administered s.c. Peptide-specific CTL and IgG responses along with cytokine levels were measured before and after vaccination. Cell surface markers in PBMCs and plasma cytokine levels were also measured. In this study, 21 advanced cancer patients, including seven lung, three breast, two pancreas, and two colon cancer patients, were enrolled. Their HLAA26 genotypes were HLA-A26:01 (n = 24), HLA-A26:03 (n = 10), and HLA-A26:02 (n = 8). One, 14, and 6 patients received two, three, and four peptides, respectively. Grade 1 or 2 skin reactions at the injection sites were observed in the majority of patients, but no severe adverse events related to the vaccination were observed. Peptide-specific CTL responses were augmented in 39% or 22% of patients after one or two cycles of vaccination, respectively. Notably, peptide-specific IgG were augmented in 63% or 100% of patients after one or two cycles of vaccination, respectively. Personalized peptide vaccines with these four CTL epitope peptides could be feasible for HLA-A26+ advanced cancer patients because of their safety and higher rates of immunological responses.
内容記述
This study was supported in part by the Japan Agency for Medical Research and development, AMED, a research program of the Regional Innovation Cluster Program of the Ministry of Education, Culture, Sports, Science and Technology of Japan, and a grant from the Sendai Kousei Hospital.
掲載誌名
Cancer Science
106巻
10号
開始ページ
1257
終了ページ
1263
出版年月日
2015-10
出版者
Wiley Publishing Asia Pty Ltd.
ISSN
1347-9032
1349-7006
出版者DOI
PubMedID
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
権利情報
© 2015 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is noncommercial and no modifications or adaptations are made.
関連情報URL
部局名
医歯薬保健学研究科