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ID 34829
本文ファイル
著者
Mukaida, Kenichi
Hattori, Noboru
Kondo, Keiichi
Morita, Naoki
Murakami, Isao
Haruta, Yoshihiro
Yokoyama, Akihito
キーワード
Bakumondoto
Multiherb Kampo medicine
Pilot study
Cough
Chronic obstructive pulmonary disease (COPD)
NDC
医学
抄録(英)
Objectives: To evaluate the effect of bakumondoto. Kampo medicine, on cough in patients with chronic obstructive pulmonary disease (COPD).
Design: A 16-week, randomized, open-labeled, cross-over design.
Setting: Outpatient clinics at one university hospital and two general hospitals in Japan from May 2007 to March 2009.
Participants: Twenty-four elderly patients (14 men and 9 women aged over 65) with COPD.
Intervention: Treatment with or without bakumondoto for 8 weeks in a cross-over design.
Measurements: The primary outcome measurements were the frequency and intensity of cough assessed by a visual analogue scale (VAS) and a daily cough diary. Secondary outcome measurements were quality of life (QOL) assessed using St. George's Respiratory Questionnaire (SGRQ) and lung functions measured using spirometry.
Results: Treatment with bakumondoto significantly improved cough severity during the first treatment period (week 0 vs. week 8, p = 0.004) and showed a trend to decrease during the second treatment period (week 8 vs. week16, p=0.129) assessed by the VAS. Neither QOL nor lung function was affected by the treatment with bakumondoto.
Conclusion: Bakumondoto may be effective in suppressing cough in elderly patients with COPD. To further confirm the efficacy, a larger and placebo-controlled study with objective cough assessment is necessary.
掲載誌名
Phytomedicine
18巻
8-9号
開始ページ
625
終了ページ
629
出版年月日
2011
出版者
Elsevier GmbH - Urban & Fischer Verlag
ISSN
0944-7113
NCID
出版者DOI
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
author
権利情報
(c) 2010 Elsevier GmbH. All rights reserved.
関連情報URL
部局名
医歯薬学総合研究科