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ID 38114
本文ファイル
著者
Mikami, Takashi
Kiya, Katsuzo
Mukada, Kazutoshi
Kawamoto, Keiichi
Hotta, Takuhiro
Uozumi, Tohru
キーワード
Lymphotoxin
Tumor necrosis factor
Glioma
Xenotransplantable tumor
NDC
医学
抄録(英)
We examined the antitumor effect of recombinant human lymphotoxin (rHuLT) on a xenotransplantable human malignant glioma line. Tumor-bearing nude mice were treated with rHuLT for three weeks following four schedules: intratumoral injection of rHuLT 20,000 units once a week, twice a week, intravenous injection once a week and twice a week. The inhibition rate of tumor growth was 98.8%, 99.1 %, 92.1 % and 98.8%, respectively. Histologically, necrotic lesions were observed in the tumors of all treated mice. Thrombo-obstructive changes of tumor vessels were also seen in the tumors of mice after intravenous injection of rHuLT. None of the mice died as a result of this treatment in spite of significant body weight loss. These results indicate that rHuLT has a strong antitumor effect on a xenotransplantable human malignant glioma line.
掲載誌名
Hiroshima Journal of Medical Sciences
38巻
3号
開始ページ
103
終了ページ
107
出版年月日
1989-09
出版者
Hiroshima University Medical Press
ISSN
0018-2052
NCID
PubMedID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
部局名
医歯薬学総合研究科
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