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ID 25934
本文ファイル
著者
キーワード
CFTR
ENaC
Fluid accumulation
Mouse uterus
SERM
NDC
医学
抄録(英)
Objectives: Estrogen regulates the expression of epithelial Na+ channel (ENaC) and cystic fibrosis transmembrane conductance regulator (CFTR). Our purpose was to assess the effects of raloxifene analogue LY117018 on the expression of ENaC and CFTR in ovariectomized mice.

Study design: Three groups of 5 female ovariectomized mice were treated with 17β-estradiol benzoate (E2), LY117018 (LY), or vehicle, respectively, for 4 to 12 weeks. Effects on the mRNA expression levels of ENaC and CFTR channels in the uterus were studied using real-time reverse transcriptase-polymerase chain reaction.

Results: E2 treatment induced CFTR expression, repressed ENaC expression and resulted in fluid accumulation in the uterus. In contrast, LY induced CFTR expression, did not repress ENaC expression, and caused no fluid accumulation.

Conclusions: Estradiol and LY117018 differentially regulate the expression of CFTR and ENaC in ovariectomized mouse uterus. This finding suggests that uterine fluid accumulation can be controlled mainly by targeting the ENaC.
掲載誌名
American Journal of Obstetrics & Gynecology
199巻
4号
開始ページ
363.e1
終了ページ
363.e6
出版年月日
2008-10
出版者
Mosby
Elsevier
ISSN
0002-9378
NCID
出版者DOI
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
author
権利情報
Copyright (c) 2008 Mosby, Inc.
関連情報URL
部局名
医歯薬学総合研究科
放射光科学研究センター