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ID 49779
本文ファイル
著者
MASAKI, Satoshi
TAKIGAWA, Hidehiko
KUNISHO, Shoma
KIMOTO, Akiko
YUGE, Ryo 病院内視鏡診療科 広大研究者総覧
TANAKA, Shinji 病院内視鏡診療科 広大研究者総覧
キーワード
Helicobacter suis
Helicobacter pylori
mucosa-associated lymphoid tissue (MALT) lymphoma
non-Helicobacter pylori Helicobacter (NHPH)
抄録(英)
Objective: In patients with Helicobacter pylori-negative gastric mucosa-associated lymphoid tissue (MALT) lymphoma, eradication therapy is only effective in some cases, suggesting that infections with non-H. pylori Helicobacter (NHPH) species may also be involved. Therefore, we examined the prevalence of infection with Helicobacter suis, an NHPH, in gastric MALT lymphoma patients.
Methods: We examined the H. suis infection status of 15 patients with H. pylori-negative gastric MALT lymphoma. To examine the infection prevalence through species-specific PCR analysis, DNA was extracted from the lymphoma lesion and the background gastric mucosa. We compared the PCR products amplified from DNA extracted from different lesions.
Results: H. suis was detected in 3 of the 15 cases (20.0%), but only in the background gastric mucosa and not in the lymphoma lesion. H. suis was completely eradicated in all three cases and two of the three cases exhibited complete remission of the lymphoma.
Conclusion: These results indicated that H. suis infection may be involved in the pathogenesis of gastric MALT lymphoma. We conclude that it is desirable to use multiple biopsies, including the background mucosa, to evaluate NHPH infection in gastric MALT lymphoma patients.
内容記述
This research was partially supported by the PUH Research Grant Program (Advanced Research A).
掲載誌名
Hiroshima Journal of Medical Sciences
69巻
2号
開始ページ
33
終了ページ
37
出版年月日
2020-06-30
出版者
Hiroshima University Medical Press
ISSN
0018-2052
2433-7668
NCID
出版者DOI
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
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application/pdf
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publisher
権利情報
Copyright (c) 2020 Hiroshima University Medical Press
関連情報URL
部局名
医系科学研究科
病院
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