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ID 17055
本文ファイル
著者
Fujiwara, Yasushi
キーワード
motor evoked potentials
central motor conduction time
spinal cord evoked potentials
cervical myelopathy
transcranial magnetic stimulation
NDC
医学
抄録(英)
Objective: The objective of this study was to analyze corticospinal function in patients with compressive cervical myelopathy and to elucidate the mechanism underlying its prolonged central motor conduction time (CMCT). Methods: Motor evoked potentials following transcranial magnetic stimulation (TMS) and peripheral conduction time in the ulnar and tibial nerves following electrical stimulation were measured from the abductor digiti minimi (ADM) and abductor hallucis (AH) muscles in 24 patients with compressive cervical myelopathy and used to calculate CMCT. Spinal cord evoked potentials (SCEPs) following transcranial electric stimulation were recorded intraoperatively from the C2-3 to C6-7 intervertebral levels. Correlations between prolonged CMCT and SCEP values were then estimated. Results: The shorter/longer CMCT between the patients' right and left ADM and AH were 8.5 ± 2.9/11.5 ± 3.3 and 16.2 ± 3.1/18.4 ± 3.3 ms, respectively (mean ± SD). The SCEPs amplitude at C6-7, compared to C2-3, was 25.7 ± 21.0 %.0 The attenuation of SCEP amplitude, but not latency, at C6-7 correlated significantly with CMCT prolongation. Conclusions: Our data support the view that CMCT prolongation is primarily due to corticospinal conduction block, rather than conduction delay. Significance: Insight was provided into the mechanism of corticospinal dysfunction in compressive cervical myelopathy.
掲載誌名
Clinical Neurophysiology
117巻
3号
開始ページ
623
終了ページ
627
出版年月日
2006-03
出版者
Elsevier
ISSN
1388-2457
NCID
出版者DOI
PubMedID
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
author
権利情報
Copyright (c) 2006 Elsevier Ltd.
関連情報URL(IsVersionOf)
http://dx.doi.org/10.1016/j.clinph.2005.11.010
部局名
医歯薬学総合研究科