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ID 47120
本文ファイル
著者
Miwata, Tomohiro
Hiyama, Tooru 保健管理センター 広大研究者総覧
Trong Quach, Duc
Le, Huy Minh
Thi, Hua Ha Ngoc
Tanaka, Shinji 病院内視鏡診療科 広大研究者総覧
Arihiro, Kouji 病院病理診断科 広大研究者総覧
Chayama, Kazuaki 大学院医歯薬保健学研究科(医) 広大研究者総覧
キーワード
Colorectal cancer
Vietnamese
Japanese
K-ras
Mitochondrial DNA
Microsatellite instability
D310
BAT-26
Mutation
NDC
医学
抄録(英)
[Background]:The incidence of early-onset (under 50 years of age) colorectal cancer (CRC) in the Vietnamese has been reported to be quite higher than that in the Japanese. To clarify the differences in genetic alterations between Vietnamese and Japanese CRCs, we investigated mutations in K-ras and mitochondrial DNA (mtDNA) and high-frequency microsatellite instability (MSI-H) in the CRCs of Vietnamese and Japanese patients.
[Methods]:We enrolled 60 Vietnamese and 233 Japanese patients with invasive CRCs. DNA was extracted from formalin-fixed, paraffin-embedded tissue sections. K-ras mutations were examined with PCR-single-strand conformation polymorphism analysis. mtDNA mutations and MSI-H were examined with microsatellite analysis using D310 and BAT-26, respectively.
[Results]:K-ras mutations were examined in 60 Vietnamese and 45 Japanese CRCs. The frequency of the mutations in the Vietnamese CRCs was significantly higher than that in the Japanese CRCs (8 of 24 [33%] vs 5 of 45 [11%], p =0.048). MSI-H was examined in 60 Vietnamese and 130 Japanese CRCs. The frequency of MSI-H in the Vietnamese CRCs was also significantly higher than that in the Japanese CRCs (6 of 27 [22%] vs 10 of 130 [8%], p =0.030). mtDNA mutations were examined in 60 Vietnamese and 138 Japanese CRCs. The frequency of mtDNA mutations in the Vietnamese CRCs was significantly higher than that in the Japanese CRCs (19 of 44 [43%] vs 11 of 133 [9%], p <0.001). There were no significant differences in clinicopathologic characteristics, such as age, sex, tumour location, and depth, in terms of tumours with/without each genetic alteration in the CRCs of the Vietnamese and Japanese patients.
[Conclusions]:These results indicate that the developmental pathways of CRCs in the Vietnamese may differ from those of CRCs in the Japanese.
掲載誌名
BMC Gastroenterology
14巻
開始ページ
203
出版年月日
2014-11-30
出版者
BioMed Central
ISSN
1471-230X
出版者DOI
PubMedID
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
権利情報
© 2014 Miwata et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
関連情報URL
部局名
保健管理センター
病院
医歯薬保健学研究科



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