Liposome collapse resulting from an allosteric interaction between 2,6‐dimethyl‐β‐cyclodextrins and lipids
RSC Advances 5 巻 95 号
77746-77754 頁
2015-09-09 発行
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| ファイル情報(添付) | |
| タイトル ( eng ) |
Liposome collapse resulting from an allosteric interaction between 2,6‐dimethyl‐β‐cyclodextrins and lipids
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| 作成者 |
Iwata Noboru
Hino Shodai
Mae Tomoya
Tsuchiya Yuki
Ohara Kazuaki
Yamaguchi Kentaro
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| 収録物名 |
RSC Advances
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| 巻 | 5 |
| 号 | 95 |
| 開始ページ | 77746 |
| 終了ページ | 77754 |
| 抄録 |
Although heptakis(2,6‐di‐O‐methyl)‐β‐cyclodextrin (DMe‐β‐CDx) has been reported to exhibit higher cytotoxicity than many other cyclodextrins because of the way in which it abstracts cholesterols from liposomes, we have identified another reason for its cytotoxicity based on its interaction with lipids. These interactions exhibited nonlinear sigmoidal responses with Hill coefficient values (n) in the range of 3.0‒3.6, which indicated that this phenomenon involves positive allosterism. Furthermore, analysis by mass spectroscopy revealed that the lipid•DMe‐β‐CDx complexes had stoichiometric ratios in the range of 1:1‒1:4.
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| 内容記述 |
Electronic supplementary information (ESI) available: Average hydrodynamic diameter values and UV-vis absorption, 1H NMR, NOESY and CSI-MS spectra. See DOI: 10.1039/c5ra14970c
This work was supported by a JSPS KAKENHI a Grant‐in‐Aid for Scientific Research (B) (Grant No. 25288037).
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| NDC分類 |
化学 [ 430 ]
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| 言語 |
英語
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| 資源タイプ | 学術雑誌論文 |
| 出版者 |
Royal Society of Chemistry
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| 発行日 | 2015-09-09 |
| 権利情報 |
This journal is © The Royal Society of Chemistry 2015
This is an open access article distributed under the terms of the Creative Commons Attribution 3.0 Unported Licence.
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| 出版タイプ | Version of Record（出版社版。早期公開を含む） |
| アクセス権 | オープンアクセス |
| 収録物識別子 |
[ISSN] 2046-2069
[DOI] 10.1039/c5ra14970c
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