In vitro organogenesis using amphibian pluripotential cells

Hiroshima Conference on Education and Science in Dentistry, 2006 : the 40th Anniversary of Hiroshima University Faculty of Dentistry 95-100 頁 2006-01-08 発行
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タイトル ( eng )
In vitro organogenesis using amphibian pluripotential cells
作成者
Asashima Makoto
Okabayashi K.
収録物名
Hiroshima Conference on Education and Science in Dentistry, 2006 : the 40th Anniversary of Hiroshima University Faculty of Dentistry
開始ページ 95
終了ページ 100
抄録
In the embryonic development of vertebrate, sequential cleavage is followed by the gastrulation as the first dynamic event of morphogenesis. Mesodermal induction is the most important event for normal body patterning such as the gastrulation, neural induction and formation of various organs. In the study to search for the mesodermal inducing factor, we reported "activin" as a strong mesoderm-inducible factor by the "animal cap assay", the in vitro assay system using amphibian pluripotential cell mass. We found that activin has mesodemal and endodermal inducing activity in dose-dependent manner, and then established the invitro induction system for various types of tissues and organs including craniofacial cartilage from animal cap cells by the treatments with activin and other inducing factors. Embryonic transplantation method showed that the treatments of animal cap cells for the induction of pronephros, beating heart were able to induce normally functional organs in vitro. These in vitro induction methods are useful for investigation of the molecular mechanisms of organ formation and body patterning in vertebrate development.
著者キーワード
activin
organogenesis
animal cap
mesoderm induction
organizer
NDC分類
医学 [ 490 ]
言語
英語
資源タイプ 会議発表論文
発行日 2006-01-08
出版タイプ Version of Record(出版社版。早期公開を含む)
アクセス権 オープンアクセス
収録物識別子
[URI] http://ir.lib.hiroshima-u.ac.jp/meta-bin/mt-pdetail.cgi?smode=1&edm=0&tlang=1&cd=00014842 ~の一部分である