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ID 39967
file
creator
Yamaguchi, Nobuo
Romaidi
Isago, Yoshiaki
Tanahashi, Hisashi
subject
Vanadium
Ascidian
Metal-binding proteins
Membrane transporters
Reductase
NDC
Biology
abstract
Several families of ascidians accumulate extremely high levels of vanadium in their blood cells. The concentration of vanadium has been determined in each species; the highest concentration, found in Ascidia gemmata, reaches 350 mM, corresponding to 107 times that of sea water. How and why ascidians accumulate vanadium in a highly selective manner and at such extremely high levels have yet to be determined. To address these questions, our research group sought to identify the genes and proteins responsible for the accumulation and reduction of vanadium in vanadocytes, a type of blood cell, as well as the process of vanadium transport from sea water to blood cells through the branchial sac, intestine, and blood plasma. Here, we review the accumulation steps as a system, especially those related to the concentration and chemical species of vanadium at each step. A comprehensive analysis on each organ has already revealed several categories of protein families, such as vanadium-binding proteins and vanadium transporters. Herein, we also discuss the mechanisms by which ascidians selectively accumulate vanadium ions from a biochemical viewpoint.
journal title
Coordination Chemistry Reviews
volume
Volume 301–302
start page
300
end page
308
date of issued
2015-10-14
publisher
Elsevier B.V.
issn
0010-8545
ncid
publisher doi
language
eng
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
author
rights
Copyright (c) 2014 Elsevier B.V. All rights reserved.
This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
relation is version of URL
http://doi.org/10.1016/j.ccr.2014.09.007
department
Graduate School of Science