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ID 770
file
title alternative
Auditory Event-related Potentials in Patients with Multiple Cerebral Infarction
creator
Zhao, Jinhua
subject
多発性脳梗塞
聴覚性事象関連電位
P300
認知機能
Habituation
NDC
Medical sciences
abstract
本研究の目的は,臨床的に痴呆を認めない慢性全期多発性脳梗塞患者の認知機能を聴覚性事象関連電位を用いて客観的に評価することである。多発性脳梗塞患者12例,健常者10例で事象関連電位を記録した。本研究の特徴はhabituationを検討するために聴覚性事象関連電位を90回連続記録したことである。90回の反応を9 block (1 block =10回加算)に分割し, Fz, Cz, Pzで記録されたN100とP300頂点潜時及び振幅を三元配置分散分析(群×電極×block)で解析した。多発性脳梗塞群では,対照群に比較してN100潜時とP300潜時の有意な延長及びP300振幅の有意な低下がみられた(p<0.05)。また,連続刺激により多発注脳梗塞群では,P300海防が次第に延長し,N100振幅が次第に低下するhabituationがみられ,健常対照群とは異なる変化がみられた。明らかな痴呆を認めない多発性脳梗塞患者においても,潜在的な注意,認知,情報処理機能障害の存在が示唆され,90回連続記録を行うことにより,habituationに関連した病的変化を検出することができた。
abstract
In the present study, we examined auditory event-related potentials in 12 non-demented patients with multiple cerebral infarction and 10 normal controls. We performed continuous recording of 90 responses induced by rare stimulation, and 90 responses were divided into nine blocks (one block=10 responses). Latencies and amplitudes of N100 and P300 recorded from Fz, Cz and Pz were analyzed by 3-way ANOVA (Group × Electrode × Block). In patients with multiple cerebral infarction, N100 and P300 latencies were significantly prolonged and P300 amplitudes were significantly decreased compared with normal controls (p<0.05). In continuous recording, P300 latency gradually prolonged and N100 amplitude gradually decreased in patients with multiple infarction but not in normal controls. We suggest that subclinical impairment of attention and cognition may exist in non-demented patients with multiple infarction and that continuous recording of 90 responses would be useful to detect delicate pathological changes related with habituation.
journal title
Medical journal of Hiroshima Universtiy
volume
Volume 51
issue
Issue 2
start page
59
end page
65
date of issued
2003-04-28
publisher
広島大学医学出版会
contributor
国立情報学研究所
date of created
2006-03-21
issn
0018-2087
ncid
SelfDOI
language
jpn
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Graduate School of Biomedical Science
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