Low high density lipoprotein cholesterol level is a significant risk factor for development of type 2 diabetes : Data from the Hawaii-Los Angeles-Hiroshima study
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低HDLコレステロール値は、2型糖尿病発症の危険因子である : ハワイ・ロサンゼルス・広島スタディより
High-density lipoprotein cholesterol
Type 2 diabetes
Aims/Introduction: A low level of high-density lipoprotein cholesterol (HDLC) is a common feature of metabolic syndrome. We have reported that Japanese-Americans who share a virtually identical genetic makeup with native Japanese, but who have lived Westernized lifestyles for decades, have lower HDLC levels and a high prevalence of type 2 diabetes compared with native Japanese. However, the impact of low HDLC level on type 2 diabetes is unclear. The aims of the present study were to evaluate whether serum HDLC level was associated with development of type 2 diabetes and if the effect might be modified by lifestyle.
Materials and Methods: We examined 1,133 non-diabetic Japanese-Americans and 1,072 non-diabetic Japanese, who underwent the 75-g oral glucose tolerance test (OGTT) and were followed for an average of 8.8 and 7.0 years, respectively. We analyzed whether serum HDLC level is a risk factor for development of type 2 diabetes based on the Cox proportional hazards model.
Results: After adjustment for age and sex, hazard ratios for development of type 2 diabetes per unit of serum HDLC level (mmol/L) were 0.292 (95% confidence interval [CI] 0.186-0.458, P < 0.0001) among Japanese-Americans and 0.551 (95% CI 0.375-0.88, P = 0.0023) among native Japanese. Comparable hazard ratios after further adjustment for category of OGTT and body mass index were 0.981 (95% CI 0.970-0.993, P = 0.0018) and 0.991 (95% CI 0.980-1.002, P = 0.112), respectively.
Conclusions: HDLC level was associated with development of type 2 diabetes in both Japanese-Americans and native Japanese. However, these results suggest that the impact of high-density lipoprotein on glucose metabolism might be affected by lifestyle.
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Thesis or Dissertation
Copyright(c) by Author
Masatoshi Hirano, Shuhei Nakanishi, Mitsunobu Kubota, Shusaku Maeda, Masayasu Yoneda, Kiminori Yamane, Sakurako Kira, Hideo Sasaki and Nobuoki Kohno; Low high-density lipoprotein cholesterol level is a significant risk factor for development of type 2 diabetes: Data from the Hawaii-Los Angeles-Hiroshima study; Journal of Diabetes Investigation, 2013 (doi: 10.1111/jdi.12170)
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Philosophy in Medical Science
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Graduate School of Biomedical Science