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ID 51556
file
creator
Yoshinaka, Asayo
subject
Amantadine
Corneal opacity
Confocal microscopy
Corneal epithelial cell deposits
abstract
Purpose
Amantadine has been reported to cause various corneal complications, such as superficial punctate keratitis, corneal endothelial dysfunction, and corneal edema. However, there have been no reports of amantadine-induced deposits in the corneal epithelium. Here, we describe the first case with amantadine-induced deposits in the corneal epithelium proved by confocal biomicroscopy.

Observations
An 81-year-old woman presented with impaired vision in both eyes. She had been treated with amantadine for 9 years. Corrected visual acuity was 0.8 in both eyes. Furthermore, both eyes showed opacities in the corneal epithelial corneal layer. On confocal biomicroscopy, there were highly reflective deposits in corneal epithelial cells. There were no pathological findings in the stroma and endothelium. Two months after discontinuation of amantadine, corneal opacities disappeared, and visual acuity was 1.0 in both eyes.

Conclusions
Administration of amantadine can cause deposits in corneal epithelial cells.
journal title
American Journal of Ophthalmology Case Reports
volume
Volume 19
start page
100852
date of issued
2020-08-05
publisher
Elsevier
issn
2451-9936
publisher doi
language
eng
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
publisher
rights
© 2020 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
relation url
department
Graduate School of Biomedical & Health Sciences