このエントリーをはてなブックマークに追加
ID 50006
file
creator
YAMAMOTO, Masami
YAMAMOTO, Tetsuro
HATA, Jotaro
NAKAGAWA, Hitoshi
NAKATSUKA, Hirofumi
TAHARA, Eiichi
subject
Colorectal cancer
Atomic bomb survivors
Immunohistochemistry
NDC
Medical sciences
abstract
In order to elucidate the biological characteristics of colorectal cancer among atomic bomb survivors in Hiroshima, a total of 159 cases of colorectal cancers comprising 73 cases in exposed atomic bomb survivors and 86 cases in non-exposed individuals were examined histologically and immunohistochemically for various functioning proteins. No statistical differences could be demonstrated in the incidence of various marker expressions of colorectal cancers between the exposed group and control group. However, comparison by the site of colorectal cancer showed that sigmoid colon cancers in the exposed group or high dose group showed a significantly higher frequency of glycoproteins such as α1-antichymotrypsin (ACT), secretory component (SC), α1-antitrypsin (AAT), and human chorionic gonadotropin (HCG) when compared with the control group. These results correlated well with the epidemiological data that the radiation effect on the incidence of colorectal cancer in atomic bomb survivors was most remarkable in the sigmoid colon.
description
This study was supported in part by Grants in Aid for Cancer Research from the Ministry of Education, Science and Culture, Japan.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 36
issue
Issue 4
start page
387
end page
393
date of issued
1987-12
publisher
Hiroshima University Medical Press
issn
0018-2052
ncid
pubmed id
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Graduate School of Biomedical Science
他の一覧