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ID 49991
file
creator
WATANABE, Akiharu
NAKATSUKASA, Harushige
KOBAYASHI, Michio
NAGASHIMA, Hideo
subject
Sake
Alcohol
Liver injury
Fatty and fibrotic liver
NDC
Medical sciences
abstract
The hepatotoxic effect on rats of long-term (55 weeks) administration of sake (a rice wine, 17% ethanol by volume) at large doses (average 12.6 g ethanol/kg body weight/day) was investigated in order to gain an insight into the reasons for the high incidence of liver fibrosis in Japanese alcoholics. Rats grew favorably under the experimental conditions, and daily variations in blood ethanol and acetaldehyde levels ranged from 3.8 to 21.1 mM and from O to 3.5 μM, respectively. Fatty and fibrotic liver was shown histologically and biochemically in sake-administered rats.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 36
issue
Issue 3
start page
277
end page
281
date of issued
1987-09
publisher
Hiroshima University Medical Press
issn
0018-2052
ncid
pubmed id
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Graduate School of Biomedical Science
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