このエントリーをはてなブックマークに追加
ID 49981
file
creator
ITANO, Satoshi
FUCHIMOTO, Sadanori
ORITA, Kunzo
subject
TNF
Interferon
Synergistic effect
NDC
Medical sciences
abstract
Referring to synergistic antitumor effects of natural human tumor necrosis factor (n-TNF) derived from human acute lymphoblastic leukemia BALL-I cell as well as mouse interferon beta (mIFNbeta) and mouse interferon gamma (mIFNgamma), a series of the study was made using Lewis lung carcinoma grafted on BDF1 mice. With a combination dose of n-TNF (1 x 10^2 U/kg/day) and mIFNbeta (1 x 10^2 IU/kg/day) as well as that of n-TNF (1 x 10^2 U/kg/day) and mIFNgamma (1 x 10^2 IU/kg/day), a significant enhancement of antitumor effect was observed. Furthermore, with a triple combination dose of n-TNF (1 x 10^2 U/kg/day), mIFNbeta (I x 10^2 IU/kg/day) and mIFNgamma (I x 10^2 IU/kg/day), too, a strong synergistic effect was noted. The concentration of n-TNF required for concomitant use with mIFNbeta and mIFNgamma was 1 over 5 x 10^3 of that required for single dose of n-TNF, to obtain the same level of effect.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 36
issue
Issue 2
start page
219
end page
225
date of issued
1987-06
publisher
Hiroshima Journal Medical Press
issn
0018-2052
ncid
pubmed id
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Graduate School of Biomedical Science
他の一覧