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ID 49914
file
creator
KANATA, Suzue
subject
Chromosome abnormality
Mental retardation
Cerebral palsy
NDC
Medical sciences
abstract
A cytogenetic study was made on heavy mentally retarded patients with cerebral palsy. The purpose of this study was to get a glimpse of the causes of mental retardation and cerebral palsy. As the results, chromosome abnormalities were found in 8.6% of the patients. By this study, it was revealed that chromosome abnormalities contribute significantly to the etiology of cerebral palsy.
The 58 cases examined in this study were admitted to National Sanatorium Kamo Hospital and Hiroshima Prefectural Handicapped Children's Hospital.
Chromosome slides were prepared in accordance with standard blood culture procedure. Karyotype analyses were made with the application of the conventional Giemsa staining and G-, C-, and Q-banding differential staining.
Of these 58 cases, 5 cases had abnormal karyotypes, showing an incidence of 8.6%. Of 5 abnormal karyotype cases, autosomal abnormalities were observed in 3 cases, and sex-chromosome abnormalities in 2 cases. And additional 4 cases had normal variations of no.1, 9, and Y chromosome. The clinical and cytogenetic findings of these patients were presented.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 35
issue
Issue 2
start page
149
end page
161
date of issued
1986-06
publisher
Hiroshima University School of Medicine
issn
0018-2052
ncid
pubmed id
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Graduate School of Biomedical Science
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