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ID 50424
file
creator
Yamazaki, Tomomi
Oomori, Yuriko
subject
Indoleamine 2,3-dioxygenase (IDO)
Trophoblast invasion
Decidua
Caesarean scar pregnancy
Placenta accreta spectrum (PAS)
abstract
Immunohistochemical localisation of indoleamine 2,3-dioxygenase was studied in order to better understand the pathophysiology of placenta accreta spectrum. In the decidua staining for indoleamine 2,3-dioxygenase was found in the glandular epithelium with some additional positive cells. Extravillous cytotrophoblast invasion was present in the myometrium which was not covered by the decidual tissue whereas myometrial invasion of cytotrophoblasts was absent where this tissue lay deep to decidua. These results suggest that indoleamine 2,3-dioxygenase expression in the decidua may normally control trophoblast invasion and absence of its expression where decidua is absent may be involved in the pathogenesis of the over-invaded placenta.
description
We are grateful to the Grant-in-Aid for Scientific Research (17K11238), Japan Society for the Promotion of Science for financial support.
journal title
Journal of Reproductive Immunology
volume
Volume 138
start page
103099
date of issued
2020-04
publisher
Elsevier
issn
0165-0378
publisher doi
pubmed id
language
eng
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
author
rights
© 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
This is not the published version. Please cite only the published version. この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。
relation url
department
Graduate School of Biomedical & Health Sciences
University Medical Hospital
Ohters
note
Post-print version/PDF may be used in an institutional repository after an embargo period of 12 months.