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ID 51067
file
creator
Ishita, Yuuki
subject
tph-1
Serotonin receptor
Pharyngeal movement
Pharyngeal pumping
Peristalsis
Environmental inputs
Pristionchus pacificus
abstract
Serotonin is a conserved neuromodulator that controls feeding behavior in response to environmental inputs in a wide range of species, including the nematode, Caenorhabditis elegans. To understand the detailed mechanism and evolution of serotonergic neuromodulation, the feeding behaviors of C. elegans and related species have been studied intensively because of their simple neural anatomy and genetic manipulability. C. elegans shows patterned movements of a feeding structure called the pharynx, and serotonin modulates feeding rhythms via several serotonin receptors expressed in pharyngeal motor neurons and muscles. Environmental inputs and physiological states like food signals, starvation, and heat affect the activity of serotonergic neurons and downstream neural pathways. We focus on serotonergic neural pathways in the feeding behavior of C. elegans and other nematodes, neuromodulation between environmental inputs and behavioral outputs, and their evolutionary path.
description
This work was supported by JSPS KAKENHI Grant Number 18K14716 to M.O. and 18H05369 to T.C. This work is also supported by the Sumitomo foundation, Grant for Basic Science Research Projects to M. O., and Toray Science Foundation and The Frontier Development Program for Genome Editing to T.C.
journal title
Neuroscience Research
volume
Volume 154
start page
9
end page
19
date of issued
2020-05
publisher
Elsevier
Japan Neuroscience Society
issn
0168-0102
publisher doi
pubmed id
language
eng
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
author
rights
© 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
This is not the published version. Please cite only the published version. この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。
relation url
department
Graduate School of Integrated Sciences for Life