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ID 50466
file
creator
Ozaki, Noritsugu
Saeki, Masayumi
Honda, Kiyomasa
Kato, Yukio
subject
circadian rhythms
DEC1
energy homeostasis
lipid metabolism
obesity
PPAR
PPRE
RXR
thermogenesis
UCP1
abstract
Obesity is a major public health problem in developed countries resulting from increased food intake and decreased energy consumption and usually associated with abnormal lipid metabolism. Here, we show that DEC1, a basic helix‐loop‐helix transcription factor, plays an important role in the regulation of lipid consumption in mouse brown adipose tissue (BAT), which is the major site of thermogenesis. Homozygous Dec1 deletion attenuated high‐fat‐diet‐induced obesity, adipocyte hypertrophy, fat volume and hepatic steatosis. Furthermore, DEC1 deficiency increased body temperature during daytime and enhanced the expression of uncoupler protein 1, a key factor of thermogenesis, and various lipolysis‐related genes in interscapular BAT. In vitro experiments suggested that DEC1 suppresses the expression of various lipolysis‐related genes induced by the heterodimer of peroxisome proliferator‐activated receptor γ and retinoid X receptor α (RXRα) through direct binding to RXRα. These observations suggest that enhanced lipolysis in BAT caused by DEC1 deficiency leads to an increase in lipid consumption, thereby decreasing lipid accumulation in adipose tissues and the liver. Thus, DEC1 may serve as an energy‐saving factor that suppresses lipid consumption, which may be relevant to managing obesity.
description
This work was supported by Grants‐in‐Aid for Science from the Japan Society for the Promotion of Science (grant numbers 22590223 and 2339042351).
journal title
Genes to Cells
volume
Volume 23
issue
Issue 8
start page
658
end page
669
date of issued
2018-08-16
publisher
Molecular Biology Society of Japan
Wiley
issn
1356-9597
1365-2443
publisher doi
pubmed id
language
eng
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
author
rights
This is the peer reviewed version of the following article: Noshiro, M, Kawamoto, T, Nakashima, A, et al. Deficiency of the basic helix‐loop‐helix transcription factor DEC1 prevents obesity induced by a high‐fat diet in mice. Genes Cells. 2018; 23: 658– 669, which has been published in final form at https://doi.org/10.1111/gtc.12607. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
This is not the published version. Please cite only the published version. この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。
relation url
department
Graduate School of Biomedical & Health Sciences
University Medical Hospital
Ohters