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ID 37735
file
creator
Asahara, Toshimasa
Yano, Masatsugu
Fukuda, Saburo
Fukuda, Toshikatsu
Nakahara, Hideki
Katayama, Koji
Itamoto, Toshiyuki
Dohi, Kiyohiko
Nakanishi, Toshio
Kitamoto, Mikiya
Azuma, Kazuyoshi
Ito, Katsuhide
Moriwaki, Katsuyuki
Yuge, Osafumi
Shimamoto, Fumio
subject
Hepatocellular carcinoma
Brain metastasis
Hepatectomy
NDC
Medical sciences
abstract
Brain metastasis from hepatocellular carcinoma (HCC) is a rare, yet perplexing problem in patients with cancer. We report on 5 patients with metastasis of HCC to the brain after radical hepatectomy. Intrahepatic recurrence occurred in 3 patients, and distant metastasis to sites other than the brain was observed in 3 patients (lung, 2; bone, 1). The symptoms for brain metastasis included headache, hemiparesis, and vomiting. Hemorrhage was found in 4 of 5 patients. All patients had a single nodular lesion in the brain. The alpha-fetoprotein levels were more than 10,000 ng/ml in 4 patients. Two patients underwent surgical resection, 1 received cranial irradiation, and 2 were administered corticosteroids. The interval between diagnosis of the primary cancer and detection of brain metastasis ranged from 2 to 54 months. The mean survival period was only 3 months after diagnosis of brain metastasis. All 5 patients died of neurologic causes. Because no effective treatment for brain metastasis from HCC is available, further study is needed.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 48
issue
Issue 3
start page
91
end page
94
date of issued
1999-09
publisher
Hiroshima University Medical Press
issn
0018-2052
ncid
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Graduate School of Biomedical Science
University Medical Hospital
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