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ID 38079
file
creator
Takesue, Yoshio
Yokoyama, Takashi
Kodama, Takashi
Sewake, Hitoshi
Miyamoto, Katsunari
Imamura, Yuuji
Tsumura, Hiroaki
Matsuura, Yuichiro
subject
β-lactamase
R plasmid
Antibiotic resistance
Chemotherapeutic agents
NDC
Medical sciences
abstract
Concomitant with the extensive use of antibiotics, the number of multiple antibiotic-resistant strains has been increasing. Since resistance is mainly mediated by R plasmids, we undertook to investigate the characteristics of R plasmid-determined ,β-lactamase in 6 Gram-negative rods.   

The β-lactamase produced by each organism was classified by its substrate: type P which attacks penicillins, type C which attacks cephalosporins, and type C/P which attacks both penicillins and cephalosporins. Though the chromosomally mediated β-lactamase of almost all Gram-negative rods is classified as type C, R plasmid-mediated β-lactamase is almost equally active against both penicillins and cephalosporins. Therefore, we suggest that type C/P ,β-lactamase was mediated by R plasmids in Gram-negative rods which already produced chromosomally mediated type C β-lactamase.   

The strains which produced type C/P β-lactamse tended to be more resistant to antibiotics than the other β-lactamase producing strains. Among type C/P strains, the sensitivity to cephalosporins varied with the bacterial species, whereas all these strains were highly resistant to penicillins. Even for piperacillin, which is stable to cephalosporinase, the MIC at which the cumulative percentage of strains inhibited was 50% (MIC50) was over 50 μg/ml in all strains tested.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 39
issue
Issue 3
start page
65
end page
69
date of issued
1990-09
publisher
Hiroshima University Medical Press
issn
0018-2052
ncid
pubmed id
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Graduate School of Biomedical Science
University Medical Hospital
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