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ID 38112
file
creator
Roy, Bidyut
Watanabe, Hiromitsu
Ito, Akihiro
subject
Rat
Methylnitrosourea
Cataract
Aggregation of βH-crystallin
NDC
Medical sciences
abstract
Cataracts were observed in female F344 rats who intravenously received methylnitrosourea (MNU), a potent carcinogen for multiple organs, in one dose of 50 mg/kg body weight. Induction of cataract 40 weeks after MNU treatment was 41 % whereas no cataract was observed in control rats. The aggregation of βH-crystallin fraction by MNU was studied in vitro. HPLC pattern ofβH-crystallin changed when lens protein was incubated for 24 hrs with MNU. HPLC patterns indicated that MNU induced high molecular weight aggregates ofβH-crystallin. This study conveys some indication about the direct interaction of MNU with lens protein in cataract formation.
description
This work was supported in part by Grant-in-Aid for Cancer Research from the Ministry of Education, Science and Culture, Japan.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 38
issue
Issue 3
start page
95
end page
98
date of issued
1989-09
publisher
Hiroshima University Medical Press
issn
0018-2052
ncid
pubmed id
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Research Institute for Radiation Biology and Medicine
Graduate School of Biomedical Science
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