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ID 38057
file
creator
Kuroi, Katsumasa
Sato, Yukio
Takayama, Takahiko
Baba, Nobutoshi
Yamaguchi, Yoshiyuki
Toge, Tetsuya
subject
Gastric cancer
Lymphocyte subpopulations
Peripheral blood
Spleen
Monoclonal antibodies
NDC
Medical sciences
abstract
Lymphocyte subpopulations in peripheral blood and the spleen from gastric cancer patients were identified by either single or two color analysis with fluorescence activated cell sorter-IV (FACS-IV) using monoclonal antibodies. The absolute and percentages of CD3+ (mature T) cells and CD4 + (helper/inducer T) cells in peripheral blood from the advanced cancer patients were significantly lower than those from normal healthy controls. In peripheral blood, a significant decrease of CD4 + cells was due to the decrease of CD4 + CD45RA + (suppressor inducer T) cells, while CDS+ CD11b+ (suppressor T) cells tended to increase with progress of the disease. CD4+ CD45RA + cells located more predominantly in peripheral blood and spleen than in the splenic vein, while CDS+ CD11b+ cells were more predominant in the splenic vein.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 39
issue
Issue 2
start page
23
end page
27
date of issued
1990-06
publisher
Hiroshima University Medical Press
issn
0018-2052
ncid
pubmed id
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Research Institute for Radiation Biology and Medicine
Graduate School of Biomedical Science
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