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ID 281
file
creator
Shiraki, Katsuhisa
Lu, Huimei
Ishimura, Yoshimasa
Kashiwabara, Shoji
Uesaka, Toshihiro
Katoh, Osamu
Watanabe, Hiromitsu
subject
Carcinogen
Rat
Mothers milk
Tumor induction
NDC
Medical sciences
abstract
In this experiment, MNU was administered, followed by MNNG, to assess effects ofsurrogate mothering on tumor. One or two day old male SD pups were treated with or without30mg/kg body weight of methylnitrosourea (MNU) and nursed by SD or ACI surrogate mothersfor 5 weeks. When 6-weeks-old they were then treated with 100ppmN-methyl-N-nitro-N-nitrosoguanidine (MNNG) or tap water for 16 weeks. The tumor incidencein the MNNG alone group was significantly lower than with MNU alone or MNU+MNNG (p<0.01).Kidney or nerve tumors mainly developed in the MNU group, gastric tumors in the MNNG group,and the two combined in the MNU+MNNG group. The incidence and mean number of tumors didnot significantly differ between the two weaning groups. However, mean survival time withthe ACI surrogate mothers after treatment with MNU was increased as compared with the SDmother group. Cumulative development of tumors in the ACI surrogate mother group was alsodelayed (p<0.05). Similar results were obtained with MNU+MNNG and MNNG alone. The presentexperiment suggested that tumor induction might be effected by components of the mother'smilk.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 51
issue
Issue 3
start page
75
end page
79
date of issued
2002-09-10
publisher
Hiroshima University Medical Press
contributor
国立情報学研究所
date of created
2006-03-21
issn
0018-2052
ncid
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Research Institute for Radiation Biology and Medicine
Graduate School of Biomedical Science
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