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ID 32411
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title alternative
Soluble Mesothelin-related Peptides (SMRP) as a Biomarker for Malignant Pleural Mesothelioma
creator
Hirashima, Tomonori
Fukuoka, Kazuya
Hida, Toyoaki
Kawahara, Kunimitsu
Kishimoto, Takumi
Matsumura, Akihide
Nakano, Kikuo
Nakano, Takashi
subject
悪性胸膜中皮腫
メソテリン
SMRP
バイオマーカー
Malignant pleural mesothelioma
Mesothelin
Soluble mesothelin-related peptides
Biomarker
NDC
Medical sciences
abstract
悪性胸膜中皮腫はアスベスト曝露に起因する難治性悪性腫瘍であり,我が国においては2030年まで増加し続けることが予測されている.これまで,悪性胸膜中皮腫のバイオマーカーについての検討は少なく,補助診断あるいは治療効果や予後予測に際して有用かつ信頼できるバイオマーカーはなかった.今回,我々は,悪性胸膜中皮腫診断における可溶型メソテリン関連蛋白(SMRP: soluble mesothelin-related peptides)のバイオマーカーとしての意義を前向きの多施設共同研究で検討した.本稿では,悪性胸膜中皮腫に関する知見,治療法,および診断のためのバイオマーカーについて特に重要な論文を中心にレビューし,さらに,我々が行った前向きの多施設共同研究の結果の一部を報告する.
abstract
Malignant pleural mesothelioma (MPM) is a highly aggressive, incurable neoplasm associated with asbestos exposure. It is estimated that the incidence of this disease will continue to increase until at least the year 2030 in Japan. There is some evidence that patients with MPM respond better to treatment if it is delivered early in the disease. A few MPM biomarkers have been reported, but until recently, no reliable serum marker to help the diagnosis of MPM or to predict response to treatment or prognosis, had been identified. Therefore, we performed a prospective, multicenter study to evaluate the significance of soluble mesothelin-related peptides (SMRP) as a biomarker for diagnosis of MPM. In this paper, we review the key advances in the understanding, treatment, and a biomarker for the diagnosis of MPM. Furthermore, we report some results of a prospective, multicenter study.
journal title
肺癌
volume
Volume 49
issue
Issue 4
start page
380
end page
385
date of issued
2009-08-20
publisher
日本肺癌学会
issn
0386-9628
ncid
publisher doi
language
jpn
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
publisher
rights
Copyright (c) 2009 日本肺癌学会
relation is version of URL
http://joi.jlc.jst.go.jp/JST.JSTAGE/haigan/49.380
department
Research Institute for Radiation Biology and Medicine