Protective effects of a water-soluble extract from cultured medium of Gall o de rIll a luciduln (Rei-shi) mycelia and Agaricus blazei murill against X-irradiation in B6C3Fl mice : Increased small intestinal crypt survival and prolongation of average time to anilnaI death
Use this link to cite this item : https://ir.lib.hiroshima-u.ac.jp/00031175
ID | 31175 |
file | |
creator |
Kubo, Nanami
Myojin, Yuki
Shimamoto, Fumio
Kashimoto, Naoki
Kyo, Eikai
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subject | radiation protection
crypt survival
survival
Ganoderma luciduml (Rei-shi) mycelia
Agaricus blazei
B6C3F1 mouse
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NDC |
Medical sciences
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abstract | Radioprotective effects of a water-soluble extracts from cultured medium of Ganoderma lucidum (Rei-shi) mycelia (designed as MAK) and Agaricus blazei (Agaricus) against the shortening of survival time or the injury of crypt by X-irradiation were investigated in male B6C3F1 mice. MAK and Agaricus at three different doses were mixed into basal diet into biscuits at 5, 2.5 and 1.25% and administered from 1 week before irradiation. MAK (5% group) significantly prolonged animal survival as compared with basal diet group (control group) after 7 Gy of X-ray irradiation at a dose rate of 2 Gy min-1. At doses of 8, 10 and 12 Gy X-irradiation at a dose rate of 4 Gy min-1 MAK (5% group) significantly increased crypt survival as compared to other groups. These results suggest that MAK can act as a radioprotective agent.
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journal title |
International Journal of Molecular Medicine
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volume | Volume 15
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issue | Issue 3
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start page | 401
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end page | 406
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date of issued | 2005-03
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publisher | Spandidos Publications Ltd.
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issn | 1107-3756
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ncid | |
language |
eng
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nii type |
Journal Article
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HU type |
Journal Articles
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DCMI type | text
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format | application/pdf
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text version | publisher
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rights | Copyright (c) 2005 Spandidos Publications Ltd.
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department |
Research Institute for Radiation Biology and Medicine
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