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ID 31175
file
creator
Kubo, Nanami
Myojin, Yuki
Shimamoto, Fumio
Kashimoto, Naoki
Kyo, Eikai
subject
radiation protection
crypt survival
survival
Ganoderma luciduml (Rei-shi) mycelia
Agaricus blazei
B6C3F1 mouse
NDC
Medical sciences
abstract
Radioprotective effects of a water-soluble extracts from cultured medium of Ganoderma lucidum (Rei-shi) mycelia (designed as MAK) and Agaricus blazei (Agaricus) against the shortening of survival time or the injury of crypt by X-irradiation were investigated in male B6C3F1 mice. MAK and Agaricus at three different doses were mixed into basal diet into biscuits at 5, 2.5 and 1.25% and administered from 1 week before irradiation. MAK (5% group) significantly prolonged animal survival as compared with basal diet group (control group) after 7 Gy of X-ray irradiation at a dose rate of 2 Gy min-1. At doses of 8, 10 and 12 Gy X-irradiation at a dose rate of 4 Gy min-1 MAK (5% group) significantly increased crypt survival as compared to other groups. These results suggest that MAK can act as a radioprotective agent.
journal title
International Journal of Molecular Medicine
volume
Volume 15
issue
Issue 3
start page
401
end page
406
date of issued
2005-03
publisher
Spandidos Publications Ltd.
issn
1107-3756
ncid
language
eng
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
publisher
rights
Copyright (c) 2005 Spandidos Publications Ltd.
department
Research Institute for Radiation Biology and Medicine