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ID 30817
file
creator
Kashiwabara, Shoji
Kashimoto, Naoki
Uesaka, Toshihiro
Wakabayashi, Keiji
subject
Gastric tumor
Azoxymethane
2-Amino-1-methyl-6-phenylimidazo [4,5-b]pyridine
F344 rats
Intestinal metaplasia
NDC
Medical sciences
abstract
Male F344 5-week-old rats were X-irradiated, and 16 weeks after the first dose. azoxymethane (AOM) was injected or 2-amino-l-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP) was given by intragastric intubation. Tumors in the pylorus of the glandular stomach were observed in 4 out of the 29 animals receiving X-rays + AOM and in 4 out of the 25 animals receiving X-rays + PhIP, 12 months after administration. No such lesions were found in the chemical or X-ray alone groups. Intestinal metaplasia and some induced tumors were positive for CDX2. It was concluded that the presence of intestinal metaplasia may increase sensitivity to the induction of gastric tumors by colon carcinogens.
journal title
Journal of Experimental & Clinical Cancer Research
volume
Volume 24
issue
Issue 2
start page
305
end page
312
date of issued
2005
publisher
BioMed Central
issn
0392-9078
ncid
language
eng
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
publisher
rights
Copyright (c) 2005 S. Kashiwabara et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
department
Research Institute for Radiation Biology and Medicine