BCR-ABL mRNA Expression in Patients with Chronic Myeloproliferative Disorders : Absence of BCR-ABL Fused Clone except Chronic Myelocytic Leukemia
Use this link to cite this item : https://ir.lib.hiroshima-u.ac.jp/00037917
ID | 37917 |
file | |
creator |
Nakata, Yoshio
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subject | Breakpoint cluster region
c-Abl
Chronic myeloproliferative disorders
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NDC |
Medical sciences
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abstract | Bcr-abl mRNA expression was studied in patients with chronic myeloproliferative disorders (CMPD) by the reverse transcriptase-polymerase chain reaction (RT-PCR) method. A bcr-abl transcript was not found in any patient with polycythemia vera, essential thrombocythemia or primary myelofibrosis, suggesting that the bcr-abl rearranged clone is not present in CMPD other than chronic myelogenous leukemia (CML). In CML clinical and laboratory data were compared from three bcr-abl types: the bcr exon 2-abl exon 2 (B2-A2) type, bcr exon 3-abl exon 2 (B3-A2) type and the co-expression type. Age at diagnosis tended to be younger (p=0.08) in the co-expression type, and the platelet count tended to be lower (p=0.11) in the B2-A2 type. However, there was no difference in other data, including the duration of the chronic phase and the phenotype of blasts at blast crisis.
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journal title |
Hiroshima Journal of Medical Sciences
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volume | Volume 42
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issue | Issue 2
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start page | 67
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end page | 71
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date of issued | 1993-06
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publisher | Hiroshima University Medical Press
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issn | 0018-2052
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ncid | |
language |
eng
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nii type |
Departmental Bulletin Paper
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HU type |
Departmental Bulletin Papers
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DCMI type | text
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format | application/pdf
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text version | publisher
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department |
Research Institute for Radiation Biology and Medicine
Graduate School of Biomedical Science
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他の一覧 |