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ID 37843
file
creator
Takimoto, Yasuo
Takafuta, Toshiro
Imanaka, Fumio
Kuramoto, Atsushi
Sasaki, Naomi
Nanba, Koji
subject
Follicular Lymphoma
Transformation
BCL2
p53
C-MYC
NDC
Medical sciences
abstract
Follicular lymphoma is a low grade malignant lymphoma. However, some follicular lymphomas undergo histological transformation into higher grade malignant lymphomas. We recently encountered a diffuse large cell lymphoma which seemed to have progressed from a follicular lymphoma and which finally transformed into a small non-cleaved lymphoma. Each stage of the histological transformation was accompanied by increasing clinical grades of malignancy. It was suspected that in our patient a follicular lymphoma initially developed due to rearrangement of the BCL2 gene, and then underwent histological transformation into a diffuse large cell lymphoma, which was associated with p53 mutation. Subsequent rearrangement of C-MYC promoted the histological transformation of this diffuse large cell lymphoma into a small non-cleaved lymphoma. Our findings indicate that p53 mutation and rearrangement of C-MYC are involved in the histological transformation of follicular lymphomas into more advanced lymphomas.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 45
issue
Issue 2
start page
69
end page
73
date of issued
1996-06
publisher
Hiroshima University Medical Press
issn
0018-2052
ncid
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Research Institute for Radiation Biology and Medicine
Graduate School of Integrated Arts and Sciences
Graduate School of Biomedical Science
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