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ID 38084
file
creator
Mtasiwa, Deodatus M.
Imamura, Nobutaka
Inada, Tominari
Takimoto, Yasuo
Okada, Kosuke
Nanba, Koji
Asaoku, Hideki
Kuramoto, Atsushi
subject
Immunophenotype
Histology
Clinical stage
Prognosis of NHL
NDC
Medical sciences
abstract
The relationship between immunophenotype, histopathology and clinical stage in influencing prognosis was evaluated in 99 cases of non-Hodgkin's lymphoma (NHL). All cases were histopathologically classified according to the system of the international conference on working formulation (WF), immunologically analysed by flow cytometry with a panel of monoclonal antibodies and clinically staged by the Ann Arbor scheme. Eighty eight percent of T- and 87.7% of B-phenotype NHLs respectively received combination chemotherapies with or without radiotherapy. Early stages I and II showed higher response rates (86% for T- and B-NHL) compared to the advanced ones III and IV (58% for T-NHL and 65% for the B-NHLs), p<0.05. Higher overall survival rates were observed in low and intermediate grade NHLs, p < 0.05. The early stages further showed relatively higher survival rates in T- than in B-phenotype of intermediate grade NHL. Low grade NHL had the highest survival rates in both early and advanced stages, whereas the survival rate was the lowest in high grade NHL irrespective of the clinical stages. Immunophenotype, pathological grade and clinical stage jointly displayed varied predictive values in the prognosis of NHL. Since the present prognostic models are based on histological and staging criteria only, the results suggest that, phenotype should be included in the classification systems or prognostic models for the NHLs, thus facilitating the establishment of effective lineage specific therapies.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 39
issue
Issue 4
start page
95
end page
102
date of issued
1990-12
publisher
Hiroshima University Medical Press
issn
0018-2052
ncid
pubmed id
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Research Institute for Radiation Biology and Medicine
University Medical Hospital
Graduate School of Integrated Arts and Sciences
Graduate School of Biomedical Science
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