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ID 38410
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title alternative
ラットにおける実験的大腸腫瘍の研究 : 第一報 1,2-ジメチルヒドラジン誘発大腸腫瘍のラット系統差について
creator
Naito, Yukiko
NDC
Medical sciences
abstract
Susceptibility to 1, 2-dimethylhydrazine (DMH) was comparatively studied using two rats strains, Wistar-Furth substrain (WF/O) rats derived from the family with a high incidence of spontaneous colon tumor, and Long-Evans (LE) rats. Ten-week-old rats of both sexes were injected with DMH (20 mg/kg body weight) weekly for 20 weeks, and sacrificed at the 10th, 15th, 20th, and 25th week after the last injection. LE rats developed colon tumors more frequently in terms of crude incidence (21/21) (p<0.01) and the number of tumors per rat (6.1) (p<0.05) than those (17/25, 2.5) in WF/O rats. The predilection site of induced tumors was the descending colon in LE rats (59/128), in which adenomas were prevailing, where only a small number of tumors were found in WF/O rats (8/42). In both strains ascending colon was far more crowded with poorly differentiated adenocarcinoma than other sites of the colon (8/19, 14/34). It is likely that a resistant rat strain (WF/O) for DMH carcinogenesis has emerged from a parent rat strain prone to develop colonic tumors spontaneously.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 30
issue
Issue 4
start page
355
date of issued
1981-12-10
publisher
Hiroshima University School of Medicine
issn
0018-2052
ncid
pubmed id
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Research Institute for Radiation Biology and Medicine
Graduate School of Biomedical Science
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