On the Study of Developmental Genetics of Isolated Pulmonary Hypoplasia
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Yi, Lee Juing
We have carried out the study on the heart anomalies of the DHS mice and Pdn mice fetuses and newborns which are known to produce genetically induced polydactyly. The results have revealed that the heart anomalies are mainly isolated hypoplasia of the pulmonary artery and that these anomalies are not always associated with polydactyly. The isolated hypoplasia of the pulmonary artery show a tendency to develop among uterine sibilings. These might suggest that the genetic traits of heart anomalies are controlled by the polygenic or multifactorial inheritances.
This study has been supported in part by Research Grants from Japanese Ministry of Education on the Experimental study of the morphogenesis of cardiovascular anomaly (448140), and on the Fine structure and pathogenesis of the heart and vessel (511102, Research Director: Professor Naomasa OKAMOTO).
Hiroshima Journal of Medical Sciences
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Hiroshima University School of Medicine
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