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ID 38178
file
title alternative
トロトラスト症患者と原爆被爆者の骨髄細胞、リンパ球にみられた血球小核と染色体異常
creator
Tanaka, Kimio
Izumi, Takaki
Ohkita, Takeshi
Kamada, Nanao
subject
Micronucleus
Chromosome aberration
Atomic bomb survivors
Thorotrast patients
NDC
Medical sciences
abstract
As two cytogenetic parameters of radiation exposure, the frequency of micronucleus in erythroblasts, lymphocytes and red cells (Howell-Jolly body) as well as chromosome aberrations in bone marrow cells and in lymphocytes were studied in 24 thorotrast patients and in 32 atomic bomb (A-bomb) survivors who were exposed within one kilometer from the Hiroshima hypocenter. The incidence of both micronucleus and chromosome aberrations in these two exposed groups were significantly higher than that in non-exposed controls. So that these two parameters are useful guide for evaluating the residual effects of radiation, especially on hematopoietic cells. Because of its simple procedures, micronucleus test is also helpful as screening for prediction of chromosome aberrations. The characteristics of lymphocyte chromosome aberrations differed considerably between thorotrast patients and A-bomb survivors; the incidence of unstable type aberrations and intracellular complexity of chromosome aberrations were much higher in the former group. The incidence of micronucleus in erythroblasts and lymphocytes was also higher in thorotrast patients. Such differences are attributable to the differences in the radiation quality (α-ray or γ-ray + neutron) and in the mode of exposure (persistent or single) of these two groups.
description
This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Health and Welfare and the Ministry of Education, Science and Culture.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 33
issue
Issue 1
start page
101
end page
111
date of issued
1984-03
publisher
Hiroshima University School of Medicine
issn
0018-2052
ncid
pubmed id
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Research Institute for Radiation Biology and Medicine
Graduate School of Biomedical Science
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