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ID 38133
file
creator
Inoh, Akira
Kodama, Yuso
Yokoro, Kenjiro
subject
MCA-sarcoma
Lymphnode metastasis
OK-432
Low dose TBI
NDC
Medical sciences
abstract
The two unique highly metastatic MCA-sarcoma cell lines have been established by the present authors. The inoculation of 1153Ln, one of the cell lines, either into footpad or subcutaneously on the back of syngeneic mice resulted in the development of metastasis exclusively in almost all lymphnodes of the body. We evaluated the therapeutic effect of a streptococcal preparation, OK-432, on the lymphnode metastasis. Two KE per mouse of OK-432 were injected intratumorally (it) at 4, 7 or 10 days after the footpad inoculation of 1153Ln. OK-432 injected it at 7 days after tumor inoculation showed an inhibition of the lymphnode metastasis. Histological findings indicated that the proliferation of lymphoid cells in the drainage node was most prominent in mice treated with OK-432 at 7 days after the tumor inoculation. A combined treatment of it and intraperitoneal (ip) injections of OK-432 significantly reduced lymphnode metastasis as compared with that of ip injection alone. This can be attributed to the fact that the activated lymphocytes induced by it-injected OK-432 exhibited a potent antimetastatic activity together with general administration (ip) of OK-432 given after surgical removal of the tumor. Low dose of total-body irradiation (TBI), known to augment the antitumor potential of tumor-bearing animals together with general application of OK-432, showed synergistic action in inhibiting tumor growth. Overall results suggest that the better antitumor effect of OK-432 can be anticipated by combination of the agent itself and with other means.
description
This work was supported by a Grant-in-Aid from the Ministry of Education, Science and Culture, Japan.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 38
issue
Issue 4
start page
213
end page
219
date of issued
1989-12
publisher
Hiroshima University Medical Press
issn
0018-2052
ncid
pubmed id
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Research Institute for Radiation Biology and Medicine
Graduate School of Biomedical Science
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