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ID 37675
file
creator
Mitsuoka, Takako
Kaseda, Yumiko
Yamashita, Hiroshi
Kohriyama, Tatsuo
Nakamura, Shigenobu
Yamamura, Yasuhiro
subject
Early-onset parkinsonism
Nicotine chewing gum
P300
UPDRS
NDC
Medical sciences
abstract
It has been reported that nicotine shows some beneficial effects on Parkinson's disease. The purpose of the present study is to assess the therapeutic effects of nicotine chewing gum in patients with early-onset parkinsonism (EOP). The subjects were 8 patients with early-onset parkinsonism (male/ female = 4/ 4, mean age; 51.3 years). Four out of 8 patients had a history of smoking (smokers). To estimate the effects of nicotine gum, the scores on the Unified Parkinson's Disease Rating Scale (UPDRS) and auditory event-related potentials (ERPs) were studied before and after taking nicotine gum in the EOP patients. In smokers, UPDRS scores improved by more than 10 % and the P300 latency of auditory ERPs was shortened by more than 30 msec. In contrast, nicotine had no remarkable effects on UPDRS scores or auditory ERPs in non-smokers. We suggest that nicotine chewing gum may be a possible choice for the treatment of patients with EOP, especially when they are smokers.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 51
issue
Issue 1
start page
33
end page
39
date of issued
2002-03
publisher
Hiroshima University Medical Press
issn
0018-2052
ncid
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Graduate School of Biomedical Science
Graduate School of Health Science
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