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ID 49943
file
creator
SANDA, Noriaki
NAKANO, Hiroshi
MIYAKE, Yoichiro
SUGINAKA, Hidekazu
NIHIRA, Hiromi
subject
Penicillin
Antibiotic resistance
Urinary tract infection
Pseudomonas aeruginosa
NDC
Medical sciences
abstract
One hundred and thirteen clinical isolates of Pseudomonas aeruginosa from urinary tract infections were tested for their mechanisms of resistance to penicillins. Ninety-eight percent and 100.0% of the strains were resistant (MIC≧100 μg/ml) to ampicillin and penicillin G, respectively, while only 5.3% were resistant to piperacillin. Low permeability of the outer membrane, and penicillinase production were involved in their resistance mechanisms. Peptidoglycan synthesis in ether-treated cells of two representative strains was inhibited by ampicillin and piperacillin at the concentrations markedly lower than that for penicillin G.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 35
issue
Issue 4
start page
355
end page
362
date of issued
1986-12
publisher
Hiroshima University School of Medicine
issn
0018-2052
ncid
pubmed id
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Graduate School of Biomedical Science
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