このエントリーをはてなブックマークに追加
ID 49939
file
creator
NAKAMURA, Koji
subject
Diethylstilbestrol
Prostatic cancer
Dihydrotestosterone
Androgen receptor
NDC
Medical sciences
abstract
A method for the radioimmunoassay of diethylstilbestrol (DES) was established to evaluate the distribution of DES in patients with prostatic carcinoma receiving intravenous infusion of 500 mg of diethylstilbestrol diphosphate (DES-DP). The plasma DES concentration was markedly elevated to 4.9 μg/ml immediately after DES-DP infusion and rapidly decreased to 0.8 μg/ml at 3 hr after the DES-DP infusion. The DES concentration in the prostatic tissue was 1.6 μgig w.w. at 1 hr after infusion, and thereafter was predominantly similar to that in the plasma. The DES excretion in the urine was 23.7 mg at 0 to 3 hr after DES-DP infusion, and decreased gradually thereafter. In addition, the DES distribution in the subcellular fractions of benign hypertrophic prostates was studied following DES-DP infusion. The DES concentration in the nuclear fraction decreased with time. Furthermore, the protein specifically bound to DES was not detected in the cytosolic fraction. Therefore, the DES converted from DES-DP did not accumulate in the prostate. Subsequently, the bioavailabilities of DES were examined. The dihydrotestosterone (DHT) content of the prostatic tissue was significantly decreased at 24 hr after DES-DP infusion. However, the cytosolic androgen receptor content was insignificantly changed within 24 hr of infusion. Since the plasma luteinizing hormone (LH) level in the castrated patient with prostatic cancer was significantly lowered 3 hr after infusion, and further decreased with time, the main effect of DES was considered to be suppression of hypophyseal function.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 35
issue
Issue 4
start page
325
end page
338
date of issued
1986-12
publisher
Hiroshima University School of Medicine
issn
0018-2052
ncid
pubmed id
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Graduate School of Biomedical Science
他の一覧