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ID 49938
file
creator
NAKAMURA, Koji
NAKAMOTO, Takahisa
NIHIRA, Hiromi
FUJIMOTO, Nariaki
ITO, Akihiro
subject
Prolactin
MtT/F84
Accessory sexual organs
Male rats
NDC
Medical sciences
abstract
A new transplantable prolactinoma, designated MtT/F84 has been serially passaged in female F344 rats. Persistently high levels of serum prolactin could be achieved in male F344 rats by MtT/F84 inoculating under the skin.
This investigation deals with the effects of hyperprolactinemia upon the accessory sexual organs of male rats during puberty. The weights and the concentrations of dihydrotestosterone (DHT) in the dorsal prostate increased significantly in rats with moderate hyperprolactinemia (756 ± 179 ng/ml), but they in rats with marked hyperprolactinemia (3612 ± 1089 ng/ml) were similar t.o those of control rats. In contrast, serum testosterone levels (0.52 ± 0/17 ng/ml) in those of hyperprolactinemic rats were significantly decreased compared to that of controls (1.11± 0.13 ng/ml).
These results suggested that the growth-promoting effect of prolactin on the rat prostate mediated through the action of androgen varied according to the degree of hyperprolactinemia.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 35
issue
Issue 4
start page
321
end page
324
date of issued
1986-12
publisher
Hiroshima University School of Medicine
issn
0018-2052
ncid
pubmed id
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Graduate School of Biomedical Science
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