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ID 102
file
creator
Kikuchi, Akira
Kinshasa, S.
subject
Wnt
β-catenin
APC
Axin
Tcf
NDC
Medical sciences
abstract
The genetics of development and cancer have converged in the identification of intra- and extra-cellular signaling pathways that are aberrantly regulated in cancer and are also central to embryonic patterning. The Wnt signaling pathway has provided an outstanding example of this. The genes for β-catenin, APC, and Axin in the Wnt signaling pathway are often mutated in human cancers. In all such cases, the common denominator is the accumulation of cytosolic and nuclear β-catenin and the activation of transcriptional factor Tcf/Lef. The resulting gene expression profile should provide a significant clue as to cancers carrying defects in the Wnt signaling pathway. In this review, the regulation of the β-catenin stability by Axin and APC, and their genetic alterations in human cancers are described.
journal title
Hiroshima Conference on Education and Science in Dentistry, 2006 : the 40th Anniversary of Hiroshima University Faculty of Dentistry
start page
101
end page
106
date of issued
2006-01-08
language
eng
nii type
Conference Paper
HU type
Conference Papers
DCMI type
text
format
application/pdf
text version
publisher
relation is part of URL
http://ir.lib.hiroshima-u.ac.jp/meta-bin/mt-pdetail.cgi?smode=1&edm=0&tlang=1&cd=00014842
department
Graduate School of Biomedical Science