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ID 49946
file
creator
TAKEMOTO, Mayumi
SAITOH, Hitoshi
MUNEOKA, Yojiro
subject
FMRFamide analog
Relaxation
Catch muscle
NDC
Medical sciences
abstract
In the anterior byssus retractor muscle (ABRM) of Mytilus, low concentrations of the molluscan neuropeptide Phe-Met-Arg-Phe-NH2 (FMRFamide) relax ACh-induced catch tension, whereas high concentrations cause contraction. In the present studies the actions of a FMRFamide-analog Trp-Nle-Arg-Phe-NH2 (W-Nle-RFamide) on the ABRM were investigated in order to compare them with those of FMRFamide.
The actions of W-Nle-RFamide were qualitatively similar to those of FMRFamide, but catch-relaxing activity of the former peptide was found to be 10-30 times more potent than that of the latter.
Cytochemical studies showed that FMRFamide-like immunoreactivity was localized to nerve branches in the ABRM and also to neurons in the pedal ganglion.
A peptide which structurally resembles FMRFamide may be involved in the mechanism of the control of relaxation of catch tension in the ABRM of Mytilus.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 35
issue
Issue 4
start page
381
end page
388
date of issued
1986-12
publisher
Hiroshima University School of Medicine
issn
0018-2052
ncid
pubmed id
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Graduate School of Biomedical Science
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