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ID 49928
file
creator
KANATA, Suzue
subject
Chromosome abnormality
Mental retardation
Behavior disorder
NDC
Medical sciences
abstract
A cytogenetic study was made on heavy mentally retarded patients with behavior disorders. The purpose of this study was to explore the causes of mental retardation and behavior disorders. As the results, chromosome abnormalities were found in 16,1 % of the patients. This study revealed that, in the mental retardates with behavior disorders, although they were not associated with gross malformations, the chromosome abnormalities were detected with a relatively high incidence as compared with the normal population.
The 56 cases examined in this study were admitted to National Sanatorium Kamo Hospital. Their common clinical signs were heavy mental retardation and behavior disorders.
Chromosome slides were prepared in accordance with the standard blood culture procedure. Karyotype analyses were made with the application of the conventional Giemsa staining and G-, C-, and Q-banding differential staining.
Of these 56 cases, 9 cases had abnormal karyotypes, showing an incidence of 16,1 %. All the abnormal karyotype cases were autosomal abnormalities. And additional 6 cases had normal variations of no.1, 9, and Y chromosomes. The clinical and cytogenetic findings of these patients were presented.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 35
issue
Issue 3
start page
253
end page
270
date of issued
1986-09
publisher
Hiroshima University School of Medicine
issn
0018-2052
ncid
pubmed id
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Graduate School of Biomedical Science
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