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ID 49921
file
creator
ITO, Akihiro
WATANABE, Hiromitsu
AOYAMA, Hideyuki
NAKAGAWA, Yoshiyuki
MORI, Masahiro
subject
Duodenal tumor
Hydrogen peroxide
1,2-dimethylhydrazine
Catalase
NDC
Medical sciences
abstract
Three different mouse strains, C3H/C^b_s C3H/HeN and B6C3 (C57BL x C3H) F1, having low, high and moderate catalase activities, were studied for duodenal tumorigenesis by the combined treatment with 1,2-dimethylhydrazine (DMH)* and hydrogen peroxide (HPO). DMH alone rarely induced duodenal tumors. Administration of HPO into 3 different mouse strains induced different frequencies of duodenal tumors ; 91.7% in C3H/C^b_s 9.5% in C3H/HeN and 31.8% in B6C3F1 mice. The incidence of duodenal tumors was significantly increased to 52.6% and 93.8% both in C3H/HeN and B6C3F1 mice by the combined administration of DMH and HPO. These increases in duodenal tumor were inversely correlated with the finding that administration of DMH or HPO alone or combined treatment of DMH and HPO significantly decreased mean blood catalase activities both in C3H and B6C3F1 mice.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 35
issue
Issue 3
start page
197
end page
200
date of issued
1986-09
publisher
Hiroshima University School of Medicine
issn
0018-2052
ncid
pubmed id
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Graduate School of Biomedical Science
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