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ID 49918
file
creator
OKUSHIN, Sayuri
TAKAISHI, Masatoshi
TAKAHASHI, Naoko
OGAWA, Takahiko
KANAHARA, Koji
HAMAGUCHI, Naoki
HIRABAYASHI, Akira
WADA, Koji
YORIOKA, Noriaki
YAMAKIDO, Michio
subject
IgA nephropathy
Immunoglobulin production
Peripheral blood mononuclear cells
NDC
Medical sciences
abstract
Immunoglobulin production by peripheral blood mononuclear cells of 27 patients of IgA nephropathy and 11 relatives was determined. In comparison with 15 healthy controls, no significant difference could be observed in both IgA nephropathy patients and relatives of the group not stimulated with PWM, but in the group stimulated with PWM a significant elevation in the production of IgA, IgG and IgM was seen in IgA nephropathy patients, while in the relatives a significant elevation in production of IgA and IgG was observed. It is speculated that immune complexes mainly IgA are the chief cause of development and progression of IgA nephropathy and that IgG and IgM are also involved. In also relatives, the presence of immunological abnormalities similar to those of IgA nephropathy patients is suggested.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 35
issue
Issue 2
start page
177
end page
182
date of issued
1986-06
publisher
Hiroshima University School of Medicine
issn
0018-2052
ncid
pubmed id
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Graduate School of Biomedical Science
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