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ID 46735
file
creator
Yoshida, Kengo
Ohishi, Waka
Nakashima, Eiji
Fujiwara, Saeko
Akahoshi, Masazumi
Kasagi, Fumiyoshi
Hakoda, Masayuki
Kyoizumi, Seishi
Nakachi, Kei
Hayashi, Tomonori
Kusunoki, Yoichiro
subject
Cohort study
hepatitis C virus
liver fibrosis
lymphocyte subset
NDC
Medical sciences
abstract
This study aims to deepen understanding of lymphocyte phenotypes related to the course of hepatitis C virus (HCV) infection and progression of liver fibrosis, in a cohort of atomic-bomb survivors. The study subjects comprise three groups: 162 HCV persistently infected, 145 spontaneously cleared, and 3511 uninfected individuals. We found increased percentages of peripheral blood TH1 and total CD8 T cells and decreased percentages of NK cells in the HCV persistence group, compared with the other two groups, after adjustment for age, gender, and radiation exposure dose. Subsequently, we found that increased TH1 cell percentages in the HCV persistence group were significantly associated with an accelerated time-course reduction in platelet counts―accelerated progression of liver fibrosis―while TC1 and NK cell percentages were inversely associated with the progression. This study suggests that TH1 immunity is enhanced by persistent HCV infection, and that percentages of peripheral TH1, TC1, and NK cells may help predict progression of liver fibrosis.
description
This research was based on RERF Research Protocols 3-09, 4-02, 2-00, 9-92, and was supported in part by the U.S. National Institute of Allergy and Infectious Diseases (NIAID Contract HHSN272200900059C).
journal title
Human Immunology
volume
Volume 72
issue
Issue 10
start page
821
end page
826
date of issued
2011-10
publisher
American Society for Histocompatibility and Immunogenetics
issn
0198-8859
1879-1166
ncid
publisher doi
language
eng
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
author
rights
Copyright (c) 2011 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
relation url
department
Graduate School of Biomedical Science